Publikationer vid IMBIM - Institutionen för medicinsk biokemi

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Metastases must be included in the differential diagnosis of any bone lesion, whether well-defined or ill-defined osteolytic or sclerotic in age > 40. Bone metastases have a predilection for hematopoietic marrow sites: spine, pelvis, ribs, cranium and proximal long bones: femur, humerus. Patient with increased PSA level: SPECT of the spine is in favour of a vertebral metastasis Prostate cancer About 40% of patients with positive scan present with no pain ->bone scan = most sensitive method for early detection of metastatic disease Incidence of skeletal metastases rises with increasing blood PSA level (In about 30% of patients receiving antiandrogen therapy, PSA is in the normal range, despite the presence of metastases) 2015-03-05 · Whether a bone metastasis is visualized on a bone scan depends on the size of the lesion, the location, and the type of bone reaction elicited. Because breast cancer metastases can be lytic, sclerotic, and frequently are mixed, a variety of manifestations are possible.

Bone scintigraphy. Bone scans are the most sensitive routine imaging modality to try and identify both sclerotic and lytic lesions 1.

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This is explained by the fact that over 30 % of bone loss must occur before a lesion becomes apparent on CT images and a much higher percentage of bone loss (about 50 %) is required for osteolysis to become evident on plain radiographs. Low incidence of bone metastases (10% of the metastases are lytic with photopenic images) Thyroid cancer Detection of metastases in well differnetiated ca can be performed using 131 scan. However, bone scan can be of interest in medullary carcinoma (which does not concentrate iodine) Hemoproliferative disorders Bone metastases, or osseous metastatic disease, is a category of cancer metastases that results from primary tumor invasion to bone.Bone-originating primary tumors such as osteosarcoma, chondrosarcoma, and Ewing's sarcoma are rare. Unlike hematological malignancies that originate in the blood and form non-solid tumors, bone metastases generally arise from epithelial tumors and form a … This lytic metastasis in the right femur (arrow) has caused significant erosion of the cortex, and is therefore at risk of causing a pathological fracture.

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This can often be prevented if the bone metastasis is found early. There are many ways to treat pain caused by bone metastases. The treatment will depend on the type of cancer as well as the number and location of bone metastases. A negative bone scan has a high negative-predictive value to exclude bone metastases and can be used as a baseline investigation. Because increased bone uptake is not specific for tumor, further evaluation of active regions with x-ray views, SPECT, SPECT/CT, or MRI is sometimes necessary for correct diagnosis.

In routine studies, images are assessed visually. Osteoblastic and osteolytic metastases exhibit increased uptake on bone scans, but very aggressive lytic lesions may not exhibit increased uptake. Bone scan is the preferred and most cost-effective imaging study to evaluate for osseous metastases. Previous treatment is highly relevant and it has been found that although the majority of untreated bone metastases are positive on PET scans and have a lytic pattern on computed tomography (CT), after treatment, incongruent CT-positive/PET-negative lesions are significantly more prevalent and generally are blastic, which presumably reflects a direct effect of treatment. Lytic bone metastases such as from renal cell and thyroid carcinoma may not induce sufficient reparative bone formation for the lesion to be detected on bone scan. B, Sagittal reformation of a CT of the spine in bone windows demonstrates lytic metastases. CT is useful for assessment of the structural integrity of the axial skeleton.
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This lytic metastasis in the right femur (arrow) has caused significant erosion of the cortex, and is therefore at risk of causing a pathological fracture. The lesion was identified initially on a staging whole body bone scan (right-hand image, arrow). This patient had breast cancer – while most metastases from breast cancer are … Breast metastases may be lytic or show a mixed lytic-blastic appearance. The majority of prostatic bone metastases are blastic though lytic lesions do occur. Bone metastases rarely present with an associated soft-tissue mass; the presence of such a mass should increase the suspicion of a primary bone tumor.

[6] Malignant bone tumors mainly metastasis and myeloma are more common in However, a bone scan may be positive in specific active benign lesions, and Bone metastases, or osseous metastatic disease, is a category of cancer metastases that results from primary tumor invasion to bone. Bone-originating primary Bone metastasis is cancer that started in another part of the body and spread to the bone. Learn about bone metastases, including treatment options.
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body PET for the evaluation of bony metastases in patients with breast cancer: comparison with 99Tcm-MDP bone scintigraphy. Nucl Med Commun. 3d ct scan showing breast metastasis in skeleton of 52 year old woman with (metastasised) to the bones.

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both lytic and sclerotic components in bone metastases, as in this case, it is predominantly lytic. Bone scan is more sensitive in the detection of bone formation than bone destruction because the principal of bone scan is the chemisorption of 99mTc-MDP into the calcium hydroxyapatite in the bone which occurs during bone formation. Abstract: Bone metastases are a common complication of advanced malignancy; however, presentation of below-the-knee metastases, particularly affecting the fibula and tibia, are infrequently observed in both the clinical setting and the literature, and present a therapeutic challenge to patients and physicians alike. ovarian metastases in the third trimester of pregnancy.