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NCT04089527 Study Connect

AIMS: To investigate the agreement of glomerular filtration rate (GFR) determination between 51Cr-ethylenediaminetetraacetic acid (51Cr-EDTA) plasma clearance (GFREDTA) and 99mTc-diethylenetriaminepentaacetic acid (99mTc-DTPA) plasma clearance (GFRDTPA), the Gates 99mTc-DTPA renographic method (GFRGates) and the serum creatinine Chronic Kidney Disease Epidemiology Collaboration equation (CKD-EPI, GFRSCr) in patients with type 2 diabetes mellitus (T2DM). Multiple sample methodThe plasma clearance of 51 Cr-EDTA for the entire group of cats ranged between 0.4 and 8.7 ml/min/kg when normalised for body weight (mean AE SD, 3.7 AE 2.5 ml/min/kg).The mean AE SD for the normal cats yielded to 2.4 AE 1.3 ml/min/kg. The mean clearance value for the hyperthyroid cats AE SD was 4.3 AE 1.9 ml/min/kg. AIM: The aim of this study was to evaluate the efficacy of 51Cr-EDTA clearance to tailor the carboplatin dose in two different therapeutic regimens of advanced epithelial ovarian cancer. MATERIALS AND METHODS: 14 patients entered the study, eight treated by carboplatin (C) alone and six by C and paclitaxel (P). A method is described whereby the plasma clearance of 51 Cr‐EDTA is used to estimate the glomerular filtration rate (GFR) in conscious rats. EDTA clearance rates were calculated based on one and two exponential disappearance curves and compared in groups of animals studied under conditions of normal, high and low GFR. 1986-01-01 · Pathology (1986), 18, pp.

51cr edta clearance method

that the 51Cr-EDTA clearance corresponds very closely with the inulin clearance when estimated by the standard infusion technique, quoting r values of 0.995 and 0.992, respectively. The renal handling of 51Cr-EDTA and inulin would therefore appear to be identical. Since "Cr-EDTA is not bound by plasma proteins and is Routine methods and their reliability for assessment of glomerular filtration rate in adults, with special reference to total [51Cr]EDTA plasma clearance Dan Med Bull . 1978 Oct;25(5):181-202. AIMS: To investigate the agreement of glomerular filtration rate (GFR) determination between 51Cr-ethylenediaminetetraacetic acid (51Cr-EDTA) plasma clearance (GFREDTA) and 99mTc-diethylenetriaminepentaacetic acid (99mTc-DTPA) plasma clearance (GFRDTPA), the Gates 99mTc-DTPA renographic method (GFRGates) and the serum creatinine Chronic Kidney Disease Epidemiology Collaboration equation (CKD-EPI, GFRSCr) in patients with type 2 diabetes mellitus (T2DM).

The aim of the present study was to compare the most commonly used GFR markers for clearance measurements, 51Cr-EDTA and iohexol, using two different methods for iohexol analysis, HPLC and X-ray fluorescence, referring both 1984-03-01 2021-03-04 In 74 adult patients suffering from various renal diseases, the total [51 Cr]EDTA plasma clearance (Cl) was compared to the [51 Cr]EDTA clearance obtained on assuming a one-pool system (Cl 1).Cl 1 always exceeded Cl, and the relative difference increased with increasing clearance values. An equation for correction is given.

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2. 51 Cr-EDTA is the most often used tracer but the x-ray contrast medium iohexol has become popular in recent years.

Skattning av njurfunktion, Methods to Estimate and - SBU

Cr-51 EDTA clearance har en mild-måttlig njurfunktionsnedsättning. filtrationsbestämning göras med 51 Cr-EDTA eller iohexol. S-Cystatin C. njurclearance med 51Cr-EDTA. [85] Nosslin B. Determination of clearance and distribution volume with the single injection technique.

In spite of its use for almost four decades, studies comparing In‐Cl and 51 Cr‐EDTA‐Cl have either not included renal transplant recipients [ 12 - 22 ] in their population study or included only a few [ 23 ]. The calculation of 51 Cr‐EDTA clearance by method II (Cl II) was based on a close relation between 51 Cr‐EDTA clearance and the reciprocal apparent volume of distribution normalized with respect to body surface area. It was demonstrated that the two methods were closely related. To test the accuracy of the two methods, the results of Cl I and CI II, were compared to 51 ‐EDTA clearance calculated by means of a standard, multiple plasma sample method … 2013-06-15 1986-01-01 A method is described whereby the plasma clearance of 51 Cr‐EDTA is used to estimate the glomerular filtration rate (GFR) in conscious rats. EDTA clearance rates were calculated based on one and two exponential disappearance curves and compared in groups of animals studied under conditions of normal, high and low GFR. Total plasma clearance of 51Cr‐EDTA, Cl, is widely used as a measure of GFR. Commonly, only the final part of the plasma concentration curve is measured, and a one‐pool clearance (slope Reassessment of a classical single injection 51Cr‐EDTA clearance method for determination of … Iohexol and 51Cr-EDTA are comparable as GFR markers for multiple-point clearance measurements. The single-sample method for GFR >40 ml/min can be used with a high accuracy. The precision and accuracy of X-ray fluorescence analysis of low concentrations of iohexol were less than those of HPLC.
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size of cationic liposomal adjuvants modifies their clearance kinetics from of immune lymphoid cells on 51-Cr-labelled allogeneic target cells in of clearance estimations with the single injection technique and without urine collec- tion. his method was further developed in Denmark using 51Cr-EDTA and Kidney Int Suppl, : S Brochner-Mortensen, J., A simple method for the Granerus, G. and M. Aurell, Reference values for 51Cr-EDTA clearance as a measure of av C Bergman · 2020 — av clearance av en specifik markör, exempelvis inulin eller iohexol (Finch, 2014).

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• In comparative studies patients with diabetes are under-represented or missing. • A close agreement is shown between 51 Cr-EDTA and 99m Tc-DTPA plasma clearance. • 99m Tc-DTPA plasma clearance can replace 51 Cr-EDTA in patients with type 2 diabetes. • Comparison of GFR measured by two different clearance clearance measured by HPLC, and one-sample iohexol methods.

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Reassessment of a classical single injection 51Cr-EDTA clearance method for determination of renal function in children and adults. Part I: Analytically correct relationship between total and one-pool clearance. 1997-10-01 · In anaesthetized pigs, clearances of 51Cr-EDTA (EDTA) and endogenous creatinine were compared with renal clearance of inulin measured during constant infusion after bolus injection.